Knottin-drug conjugates and methods of using the same

US10765625B2 · kind B2 · utility

Assignee

• The Board of Trustees of the Leland Stanford Junior University · US

Inventors

• Nicholas Raymond Cox · Seattle, US
• Jennifer R. Cochran · Stanford, US
• Mark Smith · Venetia, US
• James R. KINTZING · Concord, US

Key dates

• Filing date: Mar 14, 2017
• Grant date: Sep 8, 2020
• Expiry date: Mar 22, 2037

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K47/42
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided are knottin-drug conjugates. The conjugates include a knottin peptide that includes an engineered loop that binds to a target on a cancer cell surface, and a drug (e.g., a nucleoside drug) conjugated to the knottin peptide through a linker. Also provided are pharmaceutical compositions and kits that include the knottin-drug conjugates, as well as methods of using the knottin-drug conjugates, e.g., for therapeutic purposes.