Patent · US Active

Composition and methods for tethering bioactive peptides to metal oxide surfaces

US10765748B2 · kind B2 · utility

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20Claims
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Key dates

Filing dateJul 13, 2015
Grant dateSep 8, 2020
Priority date—
Expiry dateAug 2, 2035

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC07K14/51
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

In various aspects, embodiments of the present invention are directed to a series of multivalent dendrons containing a bioactive peptide domain and surface-binding catechol domains. In some embodiments, these multivalent dendrons were obtained through solid phase synthesis and have a strong binding affinity to metal oxide surfaces such as, TiO2, ZrO2, CeO2, and Fe3O4, SiO2, as well as other inorganic surfaces such as hydroxyapatite, silver, fluorapatite, calcium carbonate and gold. These catechol-bearing dendrons provide a fast and efficient method to functionalize a wide range of inorganic materials with bioactive peptides and have the potential to be used in coating orthopaedic implants and fixation devices.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.