Compositions and methods to modulate cell activity
US10765878B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Mar 21, 2017 |
| Grant date | Sep 8, 2020 |
| Priority date | — |
| Expiry date | Mar 21, 2037 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/042
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides methods and compositions for the remote control of cell function based on the use of a magnetic field to excite paramagnetic nanoparticles targeted to specific cell types. The cell type of interest expresses an ion channel wherein excitation of the paramagnetic nanoparticles results in a physical change that is transduced into a cellular response. Such cellular responses may include, for example, increases in gene expression resulting in production of one or more physiologically active proteins. The expression of such proteins can be used to treat a variety of different inherited or acquired diseases or disorders in a subject.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.