Polymeric forms of H-NOX proteins
US10766947B2 · kind B2 · utility
2Cited by
14References
28Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 24, 2019 |
| Grant date | Sep 8, 2020 |
| Priority date | — |
| Expiry date | Jun 24, 2039 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides polymeric H-NOX proteins for the delivery of oxygen with longer circulation half-lives compared to monomeric H-NOX proteins. Polymeric H-NOX proteins extravasate into and preferentially accumulate in tumor tissue for sustained delivery of oxygen. The invention also provides the use of H-NOX proteins as radiosensitizers for the treatment of brain cancers.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.