Binding molecules for BCMA and CD3

US10766969B2 · kind B2 · utility

Assignee

• AMGEN INC. · US

Inventors

• Peter Kufer · Munich, DE
• Tobias Raum · Munich, DE
• Patrick Hoffmann · Munich, DE
• Roman Kischel · Munich, DE
• Ralf Lutterbuese · Munich, DE
• Doris Rau · Munich, DE
• Paul Adam · Wien, AT
• Eric Borges · Weitensfeld im Gurktal, AT
• Barbara Hebeis · Cambridge, GB
• Susanne Hipp · Ingelheim am Rhein, DE

Key dates

• Filing date: Nov 15, 2012
• Grant date: Sep 8, 2020
• Expiry date: Nov 15, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/43
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to a binding molecule which is at least bispecific comprising a first and a second binding domain, wherein the first binding domain is capable of binding to epitope cluster3 of BCMA, and the second binding domain is capable of binding to the Tcell CD3 receptor complex. Moreover, the invention provides a nucleic acid sequence encoding the binding molecule, a vector comprising said nucleic acid sequence and a host cell transformed or transfected with said vector. Furthermore, the invention provides a process for the production of the binding molecule of the invention, a medical use of said binding molecule and a kit comprising said binding molecule.