Patent · US Active

Organic compounds

US10767186B2 · kind B2 · utility

2Cited by

1References

17Claims

0Family size

Assignee

Novartis AG · CH

Inventors

Yehuda G. Assaraf · Rakefet, IL
Thomas Jostock · Neuenburg am Rhein, DE
Hans-Peter Knopf · Schallstadt, DE

Key dates

Filing date	Aug 10, 2016
Grant date	Sep 8, 2020
Priority date	—
Expiry date	Aug 10, 2036

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2317/14
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The present invention relates to a novel selection system for use in a eukaryotic cell culture process and for expression of a recombinant product of interest. The selection system is based on the introduction of an exogenous functional membrane-bound folate receptor gene together with the polynucleotide or gene encoding the product of interest into a eukaryotic cell and can be widely utilized with eukaryotic cells for which cellular viability is dependent upon folic acid uptake.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.