Method for controlling histotripsy using confocal fundamental and harmonic superposition combined with hundred-microsecond ultrasound pulses

US10772646B2 · kind B2 · utility

Assignee

• XI'AN JIAOTONG UNIVERSITY · CN

Inventors

• Mingzhu Lu · Tuji, CN
• Yizhe Geng · Tuji, CN
• Ruixin LI · Tuji, CN
• Xuan Wang · Xuzhou, CN
• Yanshan LIU · Tuji, CN
• Dan Han · Weifang, CN
• Yehui Liu · Tuji, CN
• Yujiao LI · Tuji, CN
• Rui Wang · Zhanggou, CN
• Mingxi Wan · Tuji, CN

Key dates

• Filing date: May 25, 2019
• Grant date: Sep 15, 2020
• Expiry date: May 25, 2039

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61N2007/0073
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

A method for controlling a histotripsy using a confocal fundamental and harmonic superposition combined with hundred-microsecond ultrasound pulses, including: 1) positioning a target tissue by a monitoring and guiding system and adjusting a position of the target tissue to a focal point of a transducer; 2) first stage: controlling the confocal fundamental and harmonic superposition combined with hundred-microsecond ultrasound pulses to form a shock wave in a focal zone; wherein a negative acoustic pressure exceeds a cavitation threshold; an inertial cavitation occurs to generate boiling bubbles; the boiling bubbles collapse and achieve partial homogenization of the target tissue; 3) second stage: controlling the confocal fundamental and harmonic superposition combined with hundred-microsecond pulsed-ultrasound sequences to simultaneously irradiate a target zone and further mechanically disintegrate and homogenize the target tissue.