Process for early sacubitril intermediates

US10774036B2 · kind B2 · utility

Assignee

• Novartis AG · CH

Inventors

• Florian Karl Kleinbeck-Riniker · Basel, CH
• Tobias Kapferer · Cologne, DE
• Hongyong Kim · Hoherlehmer Straße, CN
• Jie Ku · Suzhou, CN
• Kurt Laumen · Wuppertal, DE
• Yunzhong Li · 安丰镇, CN
• Wei Peng · Changtu, CN
• Thomas Ruch · Frenkendorf, CH
• Thierry Schlama · Dardilly, FR
• Yao-Hsu Yang · Taipei, TW

Key dates

• Filing date: Dec 20, 2017
• Grant date: Sep 15, 2020
• Expiry date: Dec 20, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12P41/006
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to a new enantioselective process for producing useful intermediates for the manufacture of NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a γ-amino-δ-biphenyl-α-methylalkanoic acid, or acid ester, backbone.