Process for preparing 1,1,3-trioxo-1,2-benzothiazole-6-carboxamide

US10774055B2 · kind B2 · utility

Assignee

• ADAMA AGAN LTD. · IL

Inventors

• Bijukumar Gopinathan Pillai · Ahmedabad, IN
• Sima Mirilashvili · Lod, IL
• Yaniv Barda · Rehovot, IL
• Bhavinkumar P. Hamirani · Sayla, IN
• Bhoopal Meka · Chilpur, IN
• Sreedevi Mannam · Hyderabad, IN

Key dates

• Filing date: Dec 28, 2016
• Grant date: Sep 15, 2020
• Expiry date: Aug 24, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D239/69
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A process for preparing, 1,1,3-trioxo-1,2-benzothiazole-6-carboxamide of formula (I) comprising: (a) oxidizing 2,5-dimethyl-benzenesulfonamide of formula (II) in the presence of an oxidizing agent to receive 2-sulfamoyl-terephthalic acid of formula (III); (b) converting the formed 2-sulfamoyl-terephthalic acid of formula (III) to receive 2-sulfamoyl-terephthalic acid derivative of formula (IV); and (c) reacting the resulting 2-sulfamoyl-terephthalic acid derivative of formula (IV) with ammonia (NH3) or ammonium containing-salt; wherein R represents OR′ or CI and R′ represents a branched or non-branched C1-C12 alkyl.