Phosphoroamidate esters, and use and synthesis thereof
US10774105B2 · kind B2 · utility
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10Claims
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Key dates
| Filing date | Apr 10, 2019 |
| Grant date | Sep 15, 2020 |
| Priority date | — |
| Expiry date | Apr 10, 2039 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Phosphoramidate esters and related nucleotide analogs useful in polynucleotide sequencing techniques, and synthetic methods for preparing those compounds, are disclosed, including compounds having the following structure: wherein R1, R2, R3 and R4 are as defined herein. These compounds include nucleotide phosphoramidates analogs that are modified on the alpha-phosphate to enable attachment of a variety of application-specific substituents such as tether molecules.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.