IgG bispecific antibodies and processes for preparation

US10774156B2 · kind B2 · utility

Assignees

• ELI LILLY AND COMPANY · US
• The University of North Carolina at Chapel Hill · US

Inventors

• Hector Aldaz · San Marcos, US
• Shane Krummen Atwell · Carlsbad, US
• Stephen Demarest · San Diego, US
• Karen Jean Froning · Escondido, US
• Brian Arthur Kuhlman · Chapel Hill, US
• Andrew Philip Leaver-Fay · Carrboro, US

Key dates

• Filing date: Jan 21, 2016
• Grant date: Sep 15, 2020
• Expiry date: Apr 1, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/94
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The present invention provides fully IgG bi-specific antibodies comprising designed residues in the interface of the heavy chain-heavy chain (CH3/CH3) domains, processes for preparing said fully IgG bi-specific antibodies, and nucleic acids, vectors and host cells encoding the same.