Automated instrumentation for production of peptide libraries
US10774324B2 · kind B2 · utility
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15References
18Claims
0Family size
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Key dates
| Filing date | Oct 31, 2019 |
| Grant date | Sep 15, 2020 |
| Priority date | — |
| Expiry date | Oct 31, 2039 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC40B50/04
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present disclosure methods for identifying binding partners using cell surface display libraries, where the cells of the library display engineered peptides on their cell surfaces for identification of peptides that bind to targets of interest. The engineered peptides are preferably expressed in the cells under conditions that provide both secretion and display of the engineered peptides on the cell surfaces, thus providing access of the engineered peptides to identify potential binding pairs. The cell libraries cab be engineered using an automated editing system that provides for one or more targeted edits per cell.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.