Compositions and methods for manipulation of adipocyte energy consumption regulatory pathway

US10774326B2 · kind B2 · utility

Assignees

• Massachusetts Institute of Technology · US
• European Molecular Biology Laboratory · DE

Inventors

• Manolis Kellis · Boston, US
• Melina Claussnitzer · Boston, US
• Jan KORBEL · Heidelberg, DE

Key dates

• Filing date: Dec 23, 2015
• Grant date: Sep 15, 2020
• Expiry date: Dec 23, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2800/80
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided herein is a pathway for adipocyte energy consumption regulation involving ARID5B, genetic variant rs1421085, IRX3, and IRX5. Compositions and methods for modulating the pathway in vitro and in vivo for anti-cachectic and anti-obesity effects are provided. Methods of identifying subjects at risk of developing a disorder mediated by a dysregulation of the energy consumption pathway are also provided.