Laser line illuminator for high throughput sequencing

US10774371B2 · kind B2 · utility

Assignee

• Illumina, Inc. · US

Inventors

• Yinghua Sun · Lo Wu, CN
• Stanley Hong · Palo Alto, US
• Marco A. Krumbuegel · Danville, US
• Peter Clarke Newman · San Diego, US
• Simon Prince · Carlsbad, US
• Dakota Watson · San Diego, US
• Wenyi Feng · 流花街道, CN
• Andrew James Carson · Carlsbad, US
• Frederick Erie · Oceanside, US

Key dates

• Filing date: Mar 6, 2018
• Grant date: Sep 15, 2020
• Expiry date: Sep 15, 2038

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2021/6478
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Imaging systems including an objective lens and a line generation module are described herein. The objective lens may focus a first light beam emitted by the line generation module and a second light beam emitted by the line generation module at a focal point external to a sample so as to adjust line width. Line width may be increased to lower overall power density of a light beam on a surface of the sample such that the power density of the light beam on the surface of the sample is below a photosaturation threshold of a dye on the sample.