Methods of using antibodies to determine periostin levels in a sample

US10775388B2 · kind B2 · utility

Assignees

• MedImmune Limited · US
• Abbott Laboratories · US

Inventors

• Partha S. Chowdhury · Gaithersburg, US
• Reena Varkey · Gaithersburg, US
• Meina Liang · Danville, US
• Yen-Wah Lee · Gaithersburg, US
• Katie Streicher · Gaithersburg, US
• Koustubh Ranade · Gaithersburg, US
• Ethan Grant · Gaithersburg, US
• Lydia Greenlees · Gaithersburg, US
• Yihong Yao · Boyds, US
• Melissa Parker · Wilmington, US
• Gerard Davis · Libertyville, US
• Nicolette Jeanblanc · Libertyville, US
• Susan E. Brophy · Lindenhurst, US
• Bruce J. Dille · Antioch, US

Key dates

• Filing date: Feb 5, 2015
• Grant date: Sep 15, 2020
• Expiry date: Apr 28, 2036

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2800/52
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This disclosure provides a robust, sensitive, and specific assay for the detection and measurement of periostin levels in samples obtained from human patients having, or suspected of having an IL-13-mediated disease or disorder. The disclosure further provides novel antiperiostin monoclonal antibodies that recognize at least isoforms 1, 2, 3, 4, 7, and 8 of human periostin, and assay kits comprising one or more of these antibodies.