Analyzing immune signaling networks for identification of therapeutic targets in complex chronic medical disorders
US10777298B2 · kind B2 · utility
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15Claims
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Key dates
| Filing date | Oct 14, 2014 |
| Grant date | Sep 15, 2020 |
| Priority date | — |
| Expiry date | Nov 14, 2036 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG16B40/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A general method of analyzing immune signaling networks for identification of potential therapeutic targets in complex, chronic medical disorders is described. The disclosure provides the CD3−/CD56+ natural killer (NK) cell population as a potential therapeutic target in the clinically-overlapping disorders Gulf War Illness (GWI) and Myalg Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). The disclosure also provides a method for improving or restoring Natural Killer (NK) cell function by stimulating the NK cells with interleukin-15 (IL-15).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.