Pharmaceutical compositions comprising silica microspheres

US10780046B2 · kind B2 · utility

Assignee

• Sol-Gel Technologies Ltd. · IL

Inventors

• Marina Shevachman · Beer Sheva, IL
• Amira Ze'evi · Omer, IL
• Eilon Asculai · Rahat, IL
• Batella Binyaminovich · Beer Sheva, IL
• Nir Avram · Meitar, IL
• Chaim Aschkenasy · Gdera, IL

Key dates

• Filing date: Apr 17, 2019
• Grant date: Sep 22, 2020
• Expiry date: Apr 17, 2039

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K47/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Topical vaginal compositions are disclosed herein which include silica microspheres and an active ingredient in the amount of 0.001 to 15.0% w/w selected from estradiol, metronidazole, clindamycin, butoconazole, and combinations thereof. The topical compositions provide sustained release of the active ingredient so as to reduce skin irritation.