Lyophilization of RNA

US10780054B2 · kind B2 · utility

Assignee

• CureVac Real Estate GmbH · DE

Inventors

• Thomas Ketterer · Bingen, DE
• Thorsten MUTZKE · Reutlingen, DE
• Michael Wiggenhorn · Munich, DE
• Frank Schaubhut · Germering, DE
• Florian Von Der Mülbe · Stuttgart, DE

Key dates

• Filing date: Apr 15, 2016
• Grant date: Sep 22, 2020
• Expiry date: Apr 15, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N15/1003
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention is directed to the field of RNA formulation, in particular to lyophilization of RNA. The invention provides a method for lyophilization of RNA. The present invention further concerns a lyophilized composition obtainable by the inventive method, a pharmaceutical composition, a vaccine and a kit or kit of parts. Moreover, the present invention provides a novel use of a lyoprotectant for lyophilizing RNA, the use of the inventive method in the manufacture of a medicament as well as the first and second medical use of the composition obtainable by the inventive method, the pharmaceutical composition, the vaccine or the kit or kit of parts according to the invention.