Heteroaryl compounds useful as inhibitors of SUMO activating enzyme

US10780090B2 · kind B2 · utility

Assignee

• Millennium Pharmaceuticals, Inc. · US

Inventors

• Matthew O. Duffey · Chicago, US
• Dylan Bradley ENGLAND · Cambridge, US
• Brian Scott Freeze · Boston, US
• Zhigen Hu · Somerville, US
• Steven P. Langston · North Andover, US
• Charles McIntyre · Cambridge, US
• Hirotake Mizutani · Cambridge, US
• Koji Ono · Gifu, JP
• He Xu · Needham, US

Key dates

• Filing date: Apr 23, 2019
• Grant date: Sep 22, 2020
• Expiry date: Apr 23, 2039

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/65586
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are chemical entities which are compounds of formula (I): or pharmaceutically acceptable salts thereof; wherein Y, Ra, Ra′, Rb, Rc, X1, X2, X3, Rd, Z1, and Z2 have the values described herein and stereochemical configurations depicted at asterisked positions indicate absolute stereochemistry. Chemical entities according to the disclosure can be useful as inhibitors of Sumo Activating Enzyme (SAE). Further provided are pharmaceutical compositions comprising a compound of the disclosure and methods of using the compositions in the treatment of proliferative, inflammatory, cardiovascular, and neurodegenerative diseases or disorders.