Methods and compositions for treating metastatic breast cancer and other cancers in the brain
US10780182B2 · kind B2 · utility
Inventors
Key dates
| Filing date | Apr 24, 2015 |
| Grant date | Sep 22, 2020 |
| Priority date | — |
| Expiry date | Apr 24, 2035 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2750/14143
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A composition comprising at least one AAV vector formulated for central nervous system delivery is described. The composition comprises at least one expression cassette which contains sequences encoding an anti-neoplastic immunoglobulin construct for delivery to the brain operably linked to expression control sequences therefor and a pharmaceutically acceptable carrier. The anti-neoplastic immunoglobulin construct may be an immunoglobulin modified to have decreased or no measurable affinity for neonatal Fc receptor (FcRn). Also provided are methods of using these constructs in preparing pharmaceutical compositions and uses thereof in anti-neoplastic regimens, particularly for primary and/or metastatic cancers of the brain.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.