Reproduction of a stem cell niche of an organism and method for the generation thereof

US10780613B2 · kind B2 · utility

Assignees

• Technische Universität Ilmenau · DE
• UNIVERSITÄTSKLINIKUM JENA · DE

Inventors

• Andreas Schober · Erfurt, DE
• Joerg Hampl · Erfurt, DE
• Frank Weise · Weimar, DE
• Justyna Borowiec · Ilmenau, DE
• Uta Fernekorn · Erfurt, DE
• Michael Gebinoga · Ilmenau, DE
• Sukhdeep Singh · Ilmenau, DE
• Gregor Schlingloff · Ilmenau, DE
• Sebastian Haefner · Dresden, DE
• James Joseph Beck · Cary, US
• Angelika Mueller · Jena, DE
• Astrid Voigt · Jena, DE

Key dates

• Filing date: May 26, 2016
• Grant date: Sep 22, 2020
• Expiry date: Nov 12, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2535/00
• WIPO field: Optics
• WIPO sector: Instruments

Abstract

The present invention relates firstly to a method for reproducing a stem cell niche of an organism. The invention further relates to a reproduction of a stem cell niche of an organism. According to the invention, an image of a tissue of an organism is generated, which tissue comprises at least one stem cell niche. The image is filtered in order to obtain a structural pattern of the imaged stem cell niche. In a further step, a lithographic mask is generated from the structural pattern. According to the invention, a starting material of a substrate is structured by means of indirect or direct application of the lithographic mask, whereby a structured substrate is obtained which represents the reproduction of the imaged stem cell niche of the organism. The reproduction can be characterised as biolithomorphic.