Patent · US Active

Catalytic hydrogenation of substituted cyanopyridines and process for preparing substituted pyridylmethylbenzamides

US10781176B2 · kind B2 · utility

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4References

18Claims

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Assignee

BAYER CROPSCIENCE AKTIENGESELLSCHAFT · DE

Inventors

Wahed Ahmed Moradi · Monheim, DE
Gunter Schlegel · Liederbach, DE
Albert Schnatterer · Leverkusen, DE
Frank Volz

Key dates

Filing date	Apr 26, 2016
Grant date	Sep 22, 2020
Priority date	—
Expiry date	Apr 26, 2036

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D213/40
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The present invention relates to novel processes for the preparation of substituted pyridyl-methylbenzamide derivatives of formula (I), in particular 2,6-dichloro-N-{[3-chloro-5-(trifluoromethyl)-2-pyridyl]methyl}benzamide (Fluopicolide), and for the catalytic hydrogenation of substituted cyanopyridine derivatives, in particular 3-chloro-2-cyano-5-trifluoromethylpyridine [=Py-CN] to the corresponding substituted 2-methylaminopyridine derivatives, in particular 2-aminomethyl-3-chloro-5-trifluoromethylpyridine [=Py-methylamine] or salts thereof in the presence of metal catalysts such as in particular palladium catalysts, catalytic modifiers and acids.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.