Predicting cancer recurrence using local co-occurrence of cell morphology (LoCoM)
US10783627B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Feb 19, 2018 |
| Grant date | Sep 22, 2020 |
| Priority date | — |
| Expiry date | Dec 23, 2038 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG06V2201/03
- WIPO fieldComputer technology
- WIPO sectorElectrical engineering
Abstract
Embodiments include apparatus for predicting cancer recurrence based on local co-occurrence of cell morphology (LoCoM). The apparatus includes image acquisition circuitry that identifies and segments at least one cellular nucleus represented in an image of a region of tissue demonstrating cancerous pathology; local nuclei graph (LNG) circuitry that constructs an LNG based on the at least one cellular nucleus, and computes a set of nuclear morphology features for a nucleus represented in the LNG; LoCoM circuitry that constructs a co-occurrence matrix based on the nuclear morphology features, computes a set of LoCoM features for the co-occurrence matrix, and computes a LoCoM signature for the image based on the set of LoCoM features; progression circuitry that generates a probability that the region of tissue will experience cancer progression based on the LoCoM signature, and classifies the region of tissue as a progressor or non-progressor based on the probability.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.