Twin-screw dry granulation for producing solid formulations

US10786459B2 · kind B2 · utility

Assignees

• R.P. Scherer Technologies, LLC · US
• UNIVERSITY OF MISSISSIPPI · US

Inventors

• Sampada Bhaskar Upadhye · Princeton, US
• Ronald Vladyka · Raritan, US
• Michael A. Repka · Oxford, US
• Jun-Bom Park · Seoul, KR
• Roshan Vijay Tiwari · Fryeburg, US
• Hemlata Gunga Patil · Fryeburg, US
• Joseph Thomas Morott, Jr. · Morgantown, US
• Wenli Lu · Shanghai, CN

Key dates

• Filing date: Apr 21, 2017
• Grant date: Sep 29, 2020
• Expiry date: May 23, 2037

Classification

• Technology area (CPC B): Performing Operations; Transporting
• CPC primary: B29C48/92
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A dry granulation process using a twin-screw extruder for granulating a powder mixture which includes at least one active ingredient and at least one carrier. The process includes steps of kneading the powder mixture in the screw barrel of the twin-screw extruder at a barrel temperature below a melting point of the at least one active ingredient and a melting point or a glass transition temperature of the at least one carrier to provide a kneaded powder mixture, and extruding the kneaded powder mixture to form granules. Granules and tablets produced using the dry granulation process in the twin-screw extruder are also provided.