Low-retention pre-columns: a straightforward approach to enable larger injection volumes and reduce extra-column effects in HPLC
US10786755B2 · kind B2 · utility
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13Claims
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Key dates
| Filing date | Jan 6, 2017 |
| Grant date | Sep 29, 2020 |
| Priority date | — |
| Expiry date | Jan 1, 2039 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2030/387
- WIPO fieldChemical engineering
- WIPO sectorChemistry
Abstract
Low-retention pre-columns that allow increased injection volumes of solvents chromatographically stronger than the mobile phase and use of solvents with limited solubility in the mobile phase, such as ethyl acetate and MTBE. The system and method also reduces band broadening due to the extra-column effects acting upstream of the analytical column, including band broadening due to the injection process and due to the connecting tubing and fittings between the injection system and the column. A pre-column may also be used as a guard column, thereby minimizing band broadening due to the guard column.
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