Oxopiperazine helix mimetics for control of Hypoxia-Inducible gene expression
US10787424B2 · kind B2 · utility
1Cited by
6References
23Claims
0Family size
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Key dates
| Filing date | May 20, 2015 |
| Grant date | Sep 29, 2020 |
| Priority date | — |
| Expiry date | May 20, 2035 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D403/06
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to oxopiperazines that mimic helix αB of the C-terminal transactivation domain of HIF1α. Also disclosed are pharmaceutical compositions containing these oxopiperazines and methods of using these oxopiperazines (e.g., to reduce gene transcription, treat or prevent disorders mediated by interaction of HIF1a with CREB-binding protein and/or p300, reduce or prevent angiogenesis in a tissue, induce apoptosis, and decrease cell survival and/or proliferation).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.