Substituted 3-azabicyclo[3.1.0]hexanes as ketohexokinase inhibitors

US10787438B2 · kind B2 · utility

Assignee

• PFIZER INC. · US

Inventors

• Matthew S. Dowling · Old Lyme, US
• Dilinie Fernando · Brookline, US
• Kentaro Futatsugi · Sharon, US
• Kim Huard · Berkeley, US
• Thomas Victor Magee · Mystic, US
• Brian Raymer · Holliston, US
• Andre Shavnya · East Lyme, US
• Aaron Smith · North Providence, US
• Benjamin Thuma · Old Lyme, US
• Andy Tsai · Mystic, US
• Meihua Mike Tu · Mystic, US

Key dates

• Filing date: Jan 16, 2020
• Grant date: Sep 29, 2020
• Expiry date: Jan 16, 2040

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D403/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided herein are substituted 3-azabicyclo[3.1.0]hexanes as ketohexokinase inhibitors, processes to make said compounds, and methods comprising administering said compounds to a mammal in need thereof.