Spiro-fused cyclic ureas as inhibitors of rock

US10787450B2 · kind B2 · utility

Assignee

• Bristol-Myers Squibb Company · US

Inventors

• Rajeev S. Bhide · Princeton Junction, US
• Mandar Shrikrishna Bodas · Bengaluru, IN
• Pravin S. Shirude · Ashti, IN
• Sharanabasappa Patil · Raichur, IN
• Tarun Kumar Maishal · Bengaluru, IN
• Kamalraj Thiyagarajan · Vellore, IN
• Kumaresan Chinnakotti · Sankarankovil, IN
• Peter W. Glunz · Wilmington, US

Key dates

• Filing date: Jul 6, 2017
• Grant date: Sep 29, 2020
• Expiry date: Jul 6, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D491/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating cardiovascular, smooth muscle, oncologic, neuropathologic, autoimmune, fibrotic, and/or inflammatory disorders using the same.