Patent · US Active

Process for the purification of L-α-glycerophosphorylcholine

US10787469B2 · kind B2 · utility

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1References

13Claims

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Inventors

Lorenzo De Ferra · Patrica, IT
Mauro Anibaldi · Patrica, IT
Maurizio Zenoni · Paullo, IT
Fabrizio Cocchi · Roma, IT

Key dates

Filing date	Mar 21, 2019
Grant date	Sep 29, 2020
Priority date	—
Expiry date	Mar 21, 2039

Classification

Technology area (CPC G)Physics
CPC primaryG01N2030/027
WIPO fieldMeasurement
WIPO sectorInstruments

Abstract

A process for the purification of L-α-glycerophosphorylcholine is described, wherein L-α-glycerophosphorylcholine is crystallized from DMSO or from a mixture of DMSO with at least another solvent, preferably selected from water, alcohol, halogenated solvents, ethers, esters and/or amides. Such a process allows to obtain L-α-glycerophosphorylcholine having a purity greater than 99.5%, preferably greater than 99.7%, even more preferably greater than or equal to 99.9%. A method for determining the purity of L-α-glycerophosphorylcholine is also described, comprising the elution of L-α-glycerophosphorylcholine through an HPLC column having an amino stationary phase, and subsequent detection of L-α-glycerophosphorylcholine itself, and any impurity thereof, by means of an Evaporative Light Scattering Detector type.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.