Multimeric bispecific binding molecules specific for CD20 and CD3

US10787520B2 · kind B2 · utility

Assignee

• IGM Biosciences, Inc. · US

Inventors

• Bruce Keyt · Pacifica, US
• Omar Duramad · Berkeley, US
• Beatrice Tien-Yi Wang · Mountain View, US
• Ramesh Baliga · Redwood City, US
• Fen Zhang · San Francisco, US

Key dates

• Filing date: Mar 4, 2016
• Grant date: Sep 29, 2020
• Expiry date: Mar 4, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/33
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This disclosure provides pentameric and hexameric CD20 binding molecules and methods of using such molecules to direct complement-mediated, T-cell-mediated, or both complement-mediated and T-cell-mediated killing of CD20-expressing cells.