Producing mesodermal cell types and methods of using the same

US10787640B2 · kind B2 · utility

Assignee

• The Board of Trustees of the Leland Stanford Junior University · US

Inventors

• Kyle M. Loh · Stanford, US
• Irving L. Weissman · Palo Alto, US
• Lay Teng Ang · Singapore, SG
• Angela Chen · Arcadia, US

Key dates

• Filing date: Mar 2, 2016
• Grant date: Sep 29, 2020
• Expiry date: Apr 20, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2501/727
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Methods are provided for the generation of mesodermal cell types and derivatives thereof. Also provided are methods for generating purified populations of mesodermal cell types and derivatives thereof. The instant disclosure also provides methods of screening for cellular responses of the generated mesodermal cell types and derivatives thereof. Also provide are methods for screening for organismal phenotypes induced by introduction of the generated mesodermal cell types and derivatives thereof. Treatment methods making use of the generated mesodermal cell types and derivatives thereof are also provided. The instant disclosure also provides systems, compositions, and kits for practicing the methods of the disclosure.