Patent · US Active

Engineered imine reductases and methods for the reductive amination of ketone and amine compounds

US10787689B2 · kind B2 · utility

4Cited by

13References

7Claims

0Family size

Assignee

Codexis, Inc. · US

Inventors

Haibin Chen · Ningbo City, CN
Steven J. Collier · Concord, US
Jovana Nazor · Milpitas, US
Joly Sukumaran · Singapore, SG
Derek Smith · Singapore, SG
Jeffrey C. Moore · Pasadena, US
Gregory Hughes · Scotch Plains, US
Jacob Janey · New York, US
Gjalt W. Huisman · Redwood City, US
Scott J. Novick · Palo Alto, US
Nicholas J. Agard · San Francisco, US
Oscar Alvizo · Fremont, US
Gregory A. Cope · Menlo Park, US
Wan Lin Yeo · Singapore, SG
Stefanie Ng Minor · Redwood City, US

Key dates

Filing date	Oct 17, 2019
Grant date	Sep 29, 2020
Priority date	—
Expiry date	Oct 17, 2039

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY02P20/52
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.