Graphene oxide-based nanolab and methods of detecting of exosomes
US10788486B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Oct 9, 2017 |
| Grant date | Sep 29, 2020 |
| Priority date | — |
| Expiry date | Nov 6, 2037 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01L2300/0887
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A capture device for capturing a biological substance can include: a substrate; a graphene-oxide layer on the substrate; at least one polydopamine polymer coupled with the graphene-oxide; and at least one targeting receptor coupled to the polydopamine(s), wherein the targeting receptor is capable of targeting/binding with a target biological substance. The graphene-oxide may be covalently coupled with the substrate and polydopamine, and the polydopamine may be covalently coupled with the targeting receptor. The targeting receptor can be an antibody or fragment thereof. The target biological substance can be an exosome. The substrate can be a particle (e.g., magnetic, such as magnetically responsive) or a surface in a microfluidic channel. The surface can be a top surface of a post, the post having a Y-shaped cross-sectional profile. In one aspect, the substrate is a particle. The capture device can include the target biological substance bound to the targeting receptor.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.