Imaging reductions in cerebrovascular reactivity
US10791931B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Sep 21, 2015 |
| Grant date | Oct 6, 2020 |
| Priority date | — |
| Expiry date | Jun 23, 2038 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG16H30/40
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
A system for detecting an abnormality in a subject's cerebrovascular response to a vasoactive stimulus in at least one region of interest (ROI) of the subject's brain The system comprises a system for generating the vasoactive stimulus (SVS), the SVS including a gas delivery device and a control system operable to deliver controlled amounts of carbon dioxide effective to attain at least one of a series of targeted increments or decrements in the subject's PetCO2, for a series of respective intervals; an imaging system comprising an MRI scanner for generating response signals corresponding to the subject's vasoactive response to the vasoactive stimulus; and a computer for analyzing the response signals, the computer including program code for computing at least one value representing a quantitative measure of the subject's cerebrovascular reactivity for the ROI, wherein the at least one value is obtained for a specific portion of the subject's vasoactive response in the ROI, the specific portion of the subject's vasoactive response corresponding to a sub-series of the at least one of a series of targeted increments or decrements in the subject's PetCO2, the sub-series characterized …
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.