Vortioxetine pamoic acid salt and crystal form thereof

US10793536B2 · kind B2 · utility

Assignee

• SHANGHAI SYNERGY PHARMACEUTICAL SCIENCES CO., LTD · CN

Inventors

• Yunfei Li · Fremont, US
• Xiaoer XIA · Shanghai, CN
• Xin Xu · Dongying, CN
• Zhen Zhang · Shanghai, CN
• Lei Liu · Thousand Oaks, US
• Xiaojuan Zhang · Fuyang, CN
• Liming Zhang · Hangzhou City, CN
• Dongsheng Li · Shanghai, CN
• Yijin Wang · Dongguan, CN
• Jian Ge · Hubei, CN

Key dates

• Filing date: Mar 28, 2017
• Grant date: Oct 6, 2020
• Expiry date: Mar 28, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/13
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present application provides a vortioxetine pamoic acid salt, which includes a crystal form, a solvate or an amorphous substance of the vortioxetine pamoic acid salt. The present application provides a preparation method and use of the vortioxetine pamoic acid salt and the crystal form thereof. The vortioxetine pamoic acid salt prepared in the present application prolongs the residence time of the vortioxetine in vivo, achieving a slow release of the vortioxetine in vivo, and is suitable for preparing a long-acting dosage form.