Methods for separating, concentrating, and/or differentiating between cells from a cell sample
US10794827B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Apr 4, 2017 |
| Grant date | Oct 6, 2020 |
| Priority date | — |
| Expiry date | Jul 22, 2038 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2021/6439
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Embodiments are generally related to differentiating and/or separating portions of a sample that are of interest from the remainder of the sample. Embodiments may be directed towards separating cells of interest from a cell sample. In some embodiments, acoustic impedances of the cells of interest may be modified. For example, the acoustic properties of the cells of interest may be modified by attaching bubbles to the cells of interest. The cell sample may then be subjected to an acoustic wave. The cells of interest may be differentiated and/or separated from the remainder of the sample based on relative displacements and/or volumetric changes experienced by the cells of interest in response thereto. The cells of interest may be separated using a standing wave and sorted into separate channels of a flow cell. Optionally, the cells may be interrogated by a light source and differentiated by signals generated in response thereto.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.