Assays for detecting neutralizing autoantibodies to biologic therapy
US10794906B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Sep 1, 2016 |
| Grant date | Oct 6, 2020 |
| Priority date | — |
| Expiry date | Nov 20, 2037 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/525
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention provides assays for detecting and measuring the presence or level of neutralizing and non-neutralizing autoantibodies to biologics such as anti-TNFα drug therapeutics in a sample. The present invention is useful for monitoring the formation of neutralizing and/or non-neutralizing anti-drug antibodies over time while a subject is on biologic therapy. The present invention is also useful for predicting and/or determining the cross-reactivity of neutralizing anti-drug antibodies in a subject's sample with alternative biologic therapies. As such, the present invention provides information for guiding treatment decisions for those subjects receiving therapy with a biologic agent and improves the accuracy of optimizing therapy, reducing toxicity, and/or monitoring the efficacy of therapeutic treatment to biologic therapy.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.