Polymeric hGH prodrugs

US10799563B2 · kind B2 · utility

Assignee

• ASCENDIS PHARMA ENDOCRINOLOGY DIVISION A/S · DK

Inventors

• Thomas Kurpiers · Heidelberg, DE
• Harald Rau · Würzburg, DE
• Evelyn Exner · Schallstadt, DE
• Steen Jensen
• Grethe Nørskov Rasmussen · Farum, DK
• Torben Lessmann · Neustadt an der Weinstraße, DE
• Thomas Wegge · Heidelberg, DE
• Alina Hermann · Schriesheim, DE
• Nina Schubert · Stuttgart, DE
• Anna Splanemann · Heidelberg, DE
• Joachim Zettler · Heidelberg, DE

Key dates

• Filing date: Nov 17, 2015
• Grant date: Oct 13, 2020
• Expiry date: Nov 17, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C08G2650/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to a polymeric human growth hormone prodrug and dry, liquid and reconstituted pharmaceutical formulations comprising said prodrug. It furthermore relates to their use as medicaments for the treatment of diseases which can be treated with growth hormone and to methods of treatment. It also relates to methods of application of such polymeric human growth hormone prodrug or pharmaceutical formulation.