Process for the preparation of acalabrutinib
US10800787B2 · kind B2 · utility
7Cited by
2References
10Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 17, 2018 |
| Grant date | Oct 13, 2020 |
| Priority date | — |
| Expiry date | Apr 17, 2038 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01J31/2295
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides processes for the preparation of Acalabrutinib (1), as well as intermediates useful in the preparation thereof. In particular, processes are provided for coupling of a compound of Formula (5) and 2-butynoic acid in the presence of Carbodiimide (8) to afford Acalabrutinib (1).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.