Methods, compositions, devices, and kits, for performing phospholipid separation

US10800799B2 · kind B2 · utility

Assignee

• Waters Technologies Corporation · US

Inventors

• Pamela C. Iraneta · Watertown, US
• Thomas H. Walter · Ashland, US
• Xin Zhang · Newton, US
• Daniel P. Walsh · Danvers, US
• Kevin D. Wyndham · Upton, US
• Raymond P. Fisk · Norton, US

Key dates

• Filing date: Mar 30, 2018
• Grant date: Oct 13, 2020
• Expiry date: Feb 26, 2039

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2030/8813
• WIPO field: Chemical engineering
• WIPO sector: Chemistry

Abstract

Methods, kits and devices for separating phospholipids and proteins from small molecules in biochemical samples can feature an apparatus having a wetting barrier, at least one frit and a separation media. For example, an apparatus can include at least one wall defining a chamber having an exit and an entrance; a wetting barrier disposed between the exit and entrance, so as to define a separation media space located between the wetting barrier and the exit and a sample receiving area located between the wetting barrier and the entrance; and a separation media disposed adjacent to the wetting barrier and having a specific affinity for phospholipids.