Patent · US Active

TGR5 modulators and methods of use thereof

US10800807B2 · kind B2 · utility

3Cited by

8References

17Claims

0Family size

Assignee

Intercept Pharmaceuticals, Inc. · US

Inventors

Roberto Pellicciari · Perugia, IT
Antimo Gioiello · Perugia, IT
Antonio Macchiarulo · Perugia, IT
Françoise Perron-Sierra · Paris, FR
Klaus Seedorf · Hamburg, DE

Key dates

Filing date	Jun 16, 2016
Grant date	Oct 13, 2020
Priority date	—
Expiry date	Jun 16, 2036

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07J71/0005
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The application relates to compounds of formula A: or a salt, solvate, ester, tautomer, amino acid conjugate, or metabolite thereof. The compounds of formula A are TGR5 modulators useful for the treatment of various diseases, including metabolic disease, inflammatory disease, autoimmune disease, cardiac disease, kidney disease, cancer, and gastrointestinal disease.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.