Patent · US Active

Co-stimulatory domains for use in genetically-modified cells

US10800833B2 · kind B2 · utility

5Cited by
19References
23Claims
0Family size

Assignee

Inventors

Key dates

Filing dateOct 11, 2019
Grant dateOct 13, 2020
Priority date—
Expiry dateOct 11, 2039

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC12N2750/14143
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

The present disclosure provides novel co-stimulatory domains useful in genetically-modified cells to promote cell proliferation and/or promote cytokine secretion after antigen recognition. For example, disclosed herein are genetically-modified cells comprising a chimeric antigen receptor or an inducible regulatory construct incorporating the co-stimulatory domains disclosed herein. Also disclosed herein are plasmids and viral vectors comprising a nucleic acid sequence encoding the co-stimulatory domains, and methods of administering compositions comprising the novel co-stimulatory domains to subjects in order to reduce the symptoms, progression, or occurrence of disease, such as cancer.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.