Compositions and methods for generating a persisting population of T cells useful for the treatment of cancer

US10800840B2 · kind B2 · utility

Assignee

• The Trustees of the University of Pennsylvania · US

Inventors

• Matthew J. Frigault · Philadelphia, US
• Yangbing Zhao · Cherry Hill, US
• John Scholler · Narberth, US
• Carl H. June · Yeadon, US

Key dates

• Filing date: Jun 21, 2018
• Grant date: Oct 13, 2020
• Expiry date: Jun 21, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2840/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides compositions and methods for generating a genetically modified T cells comprising a chimeric antigen receptor (CAR) having an antigen binding domain, a transmembrane domain, a costimulatory signaling region, and a CD3 zeta signaling domain, wherein the T cell exhibits prolonged exponential expansion in culture that is ligand independent and independent of the addition of exogenous cytokines or feeder cells.