Methods and pharmaceutical compositions for expressing a polynucleotide of interest in the peripheral nervous system of a subject

US10801040B2 · kind B2 · utility

Assignees

• INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) · FR
• UNIVERSITÉ PARIS-SUD · DE
• COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES · FR
• ASSISTANCE PUBLIQUE—HÔPITAUX DE PARIS (APHP) · FR
• Universite De Montpellier · FR

Inventors

• Patrick Aubourg · Granville, US
• Nicolas TRICAUD · Montpellier, FR
• Benoît GAUTIER · Le Kremlin-Bicêtre, FR

Key dates

• Filing date: Jul 6, 2016
• Grant date: Oct 13, 2020
• Expiry date: Jan 16, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2750/14171
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to methods and pharmaceutical compositions for expressing a polynucleotide of interest in the peripheral nervous system of a subject. In particular, the present invention relates to a method for selectively expressing a polynucleotide of interest in the peripheral nervous system of a subject in need thereof comprising the step of transducing a peripheral nerve of the subject with an amount of an AVV9 vector containing the polynucleotide of interest.