Methods for making chemoautotrophic cells by engineering an energy conversion pathway and a carbon fixation pathway

US10801045B2 · kind B2 · utility

Assignee

• Ginkgo Bioworks, Inc. · US

Inventors

• Curt R. Fischer · Sunnyvale, US
• Austin J. Che · Boston, US
• Reshma P. Shetty · Boston, US
• Jason R. Kelly · Boston, US

Key dates

• Filing date: Jan 10, 2018
• Grant date: Oct 13, 2020
• Expiry date: Jan 10, 2038

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02E50/30
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The present disclosure identifies pathways, mechanisms, systems and methods to confer chemoautotrophic production of carbon-based products of interest, such as sugars, alcohols, chemicals, amino acids, polymers, fatty acids and their derivatives, hydrocarbons, isoprenoids, and intermediates thereof, in organisms such that these organisms efficiently convert inorganic carbon to organic carbon-based products of interest using inorganic energy, such as formate, and in particular the use of organisms for the commercial production of various carbon-based products of interest.