Method for the diagnosis of bornavirus infection

US10802024B2 · kind B2 · utility

Assignee

• EUROIMMUN Medizinische Labordiagnostika AG · DE

Inventors

• Erik Lattwein · Stade, DE
• Wolfgang Meyer · Campbell, US
• Wolfgang Schlumberger · Langenau, DE
• Julia Janz · Westerburg, DE
• Anthonina Ott · Schiphorst, DE
• Thomas Scheper · Berkenthin, DE
• Jonas Schmidt-Chanasit · Berlin, DE
• Dennis Tappe · Hamburg, DE

Key dates

• Filing date: Dec 20, 2018
• Grant date: Oct 13, 2020
• Expiry date: Dec 20, 2038

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2469/10
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

A method for diagnosing a limbic encephalitis, PNS, encephaloymyelitis, leukoencephalopathy, retinitis or optic atrophy, includes detecting a bornavirus in a sample, preferably from the group comprising mammalian 2 bornavirus, even more preferably VSBV-1, and mammalian 1 bornavirus, even more preferably BoDV-1; to a carrier containing a means for the capture of an antibody against at least one polypeptide selected from the group of BoDV-1-N, BoDV-1-P, VSBV-N and VSBV-P. A kit contains the carrier and a means for the detection of a captured antibody and a control for the detection of the presence of a sample. The carrier or kit or of a primer can be used for the detection of a bornavirus or a probe can be used for the diagnosis of an encephalitis, for the prognostication of post-transplantation complications, for the monitoring of a therapy of an encephalitis or of post-transplantation complications or for the differentiation between an autoimmune encephalitis and an encephalitis caused by infection.