Patent · US Active

Mutated truncated von Willebrand Factor

US10806774B2 · kind B2 · utility

1Cited by

4References

42Claims

0Family size

Assignee

CSL BEHRING LENGNAU AG · CH

Inventors

Arna Elizabeth Andrews · Melbourne, AU
Con Panousis · Melbourne, AU
Kerstin Emmrich · Preston, AU
Michael Wilson · Colchester, GB
Steve Dower · Melbourne, AU
Matthew HARDY · Whittlesea, AU
Dallas Hartman · Elmore, AU

Key dates

Filing date	Jan 6, 2017
Grant date	Oct 20, 2020
Priority date	—
Expiry date	Jan 6, 2037

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2319/31
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention provides a modified polypeptide which binds Factor VIII. The polypeptide comprises truncated von Willebrand Factor (VWF) which comprises a sequence as shown in SEQ ID NO:3 or a fragment thereof or a sequence 90% identical thereto, wherein the truncated VWF comprises at least one modification in comparison to SEQ ID NO: 3 in at least one position selected from the group consisting of SI, S3, LI 8, V42, S43, K149, N248, S279, V320, T325, Q395 and K418.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.