Immunomodulator compounds and methods of use
US10806785B2 · kind B2 · utility
28Cited by
18References
17Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Dec 21, 2017 |
| Grant date | Oct 20, 2020 |
| Priority date | — |
| Expiry date | Aug 9, 2038 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2039/55511
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Compositions and methods for inducing PD-L1 internalization are disclosed. The methods include reducing the amount of cell surface PD-L1 by contacting a cell expressing PD-L1 with a compound that binds to cell surface PD-L1 and induces PD-L1 internalization. Compounds that induce PD-L1 internalization can be used to enhance, stimulate and/or increase an immune response and treat a PD-1-related disease or condition.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.