Aromatic compounds and uses thereof

US10807948B2 · kind B2 · utility

Assignee

• Peloton Therapeutics, Inc. · US

Inventors

• Darryl David Dixon · Somerville, US
• Jonas Grina · Coppell, US
• John A. Josey · Dallas, US
• James P. Rizzi · Niwot, US
• Stephen T. Schlachter · Boulder, US
• Eli M. Wallace · Richardson, US
• Bin Wang · Beijing, CN
• Paul Wehn · Dallas, US
• Rui Xu · Boulder, US
• Hanbiao Yang · Sunnyvale, US

Key dates

• Filing date: Mar 4, 2016
• Grant date: Oct 20, 2020
• Expiry date: Mar 4, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2602/08
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed herein are substituted indane derivatives useful as HIF-2α inhibitors. Pharmaceutical compositions comprising said indane derivatives and methods of using said indane derivatives for treating proliferative diseases, such as renal cell carcinoma and von Hippel-Lindau disease, and other conditions associated with HIF-2α activity are also disclosed.