IL-15/IL-15Ralpha based conjugates purification method
US10808022B2 · kind B2 · utility
1Cited by
25References
10Claims
0Family size
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Key dates
| Filing date | Mar 3, 2015 |
| Grant date | Oct 20, 2020 |
| Priority date | — |
| Expiry date | Jul 5, 2035 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/00
- WIPO fieldChemical engineering
- WIPO sectorChemistry
Abstract
The present invention relates to a method for preparing a composition comprising monomeric conjugates from a sample, said conjugate comprising (a) a polypeptide comprising the amino acid sequence of interleukin 15 or derivatives thereof, and (b) a polypeptide comprising the amino acid sequence of the sushi domain of IL-15Rα or derivatives thereof; wherein said method comprises the use of anion-exchange chromatography followed by a hydrophobic interaction chromatography; and to a pharmaceutical composition which can be obtained by such a method.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.